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Monkeys Don't Smoke, Stop OHSU Experiments



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DUH: SMOKING IS ADDICTIVE. IN HUMANS, NOT MONKEYS
Pump nicotine into monkeys? Already known: Smoking harms fetuses and promotes cancer of the lungs, larynx, tongue, salivary glands, pharynx, esophagus. Already known: Smoking is linked to coronary heart disease, strokes, pulmonary illness. Duh: Smoking is addictive.

Animals acquire nicotine intravenously; humans inhale it. Animals receive mass doses in brief intervals, while people get small quantities over long period. Data from distressed animals is so misleading, early experiments led to a tobacco industry claim that nicotine is harmless!

PHOTOS: Oregon Health and Science University (OHSU) experimenter Eliot Spindel has been killing infant monkeys (like Thimble, pictured here) in nicotine studies for 24 years. But that's not enough for him. Spindel has a ticket to ride the federally-funded gravy train and continue these needless experiments until 2012.

Uncertain and misleading data: The animal model presumes that a harmful impact seen in one species will happen in other species. At the same time, science acknowledges that various species interact differently with the same test compound (Ekwall, et al., 1998; Hurtt, et al., 2003; Gold & Slone, 1993).

Animal tests are inconsistent with the human experience: Animals mega-dosed with a drug, chemical or ingredient do not reflect human intake or exposure levels. (Muller, 1948; ACSH, 1997). Artificial and induced means of producing disease or injury (i.e., purposefully grown tumors, deliberately broken bones, surgically implanted dysfunction, etc.) generate results that are unlikely, in some cases impossible, to reproduce (Weil & Scala, 1971; Bremer, et al., 2007; Gottmann, et al., 2001).

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Dear Dr. Nabel and Dr. Robertson,

I am astonished Eliot Spindel of Oregon Health and Science University receives millions from the National Institutes of Health's (NIH) National Heart, Lung, and Blood Institute to conduct nicotine experiments upon monkeys. I respectfully ask you to stop funding these irrelevant studies.

Since 1972, NIH has awarded Spindel $7.6 million taxpayer dollars to dose pregnant monkeys with nicotine via pumps embedded in their backs. Spindel has failed to produce data that can't already be gleaned from human clinical studies. Yet NIH intends to subsidize his experiments through 2012.

Please invest federal money in education, prevention and smoking cessation programs. It is fundamentally futile to pump nicotine into monkeys. We know smoking harms fetuses and promotes cancer of the lungs, larynx, tongue, salivary glands, pharynx, and esophagus. We understand its link to coronary heart disease, strokes, and pulmonary illness. We already know smoking is very addictive.

Moreover, animals acquire nicotine intravenously whereas humans inhale it. Animals receive mass doses in brief intervals, while people encounter small quantities over long period. In 1999, Science Journal reported the way a drug digests contrasts widely from one species to another. By the time a monkey excretes a drug, it doesn't look like the same drug in a human.

In fact, data derived from distressed animals is so misleading, early experiments prompted the tobacco industry to dub nicotine harmless. Epidemiological and clinical studies – not animal experiments – have disclosed all applicable data about smoking-related diseases in people.

Nonetheless, Eliot Spindel squanders millions to impregnate monkeys and implant nicotine-dosing pumps in their backs. Females endure up to five surgeries as pumps are modified during pregnancy. Fetuses are cut out and killed during different developmental phases. Their lungs are dissected.

One caretaker who worked in Spindel's lab for two years stated: "Among the most horrifying things I witnessed at the lab were the times baby monkeys were stolen away from their mothers... A worker reached into the cage to rip the baby from her mother, who screamed and fought to keep her baby safe. Once removed, the entire room of monkeys erupted into pandemonium – screaming, thrashing, and crashing against the sides of their cages."

Some might attempt to argue animal suffering serves a higher purpose. But Spindel's lab doesn't serve progress. Please cut funds for these indisputably cruel experiments at Oregon Health and Science University.

Thank you,

YOUR FULL NAME
ADDRESS, CITY, STATE
COUNTRY

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Elizabeth G. Nabel, M.D.
Director, National Heart, Lung and Blood Institute

Building 31, Room 5A48
31 Center Dr. MSC 2486
Bethesda, MD 20892
ph: 301-496-5166
email: nabele@nhlbi.nih.gov
Joseph Robertson, Jr., M.D., MBA, President of OHSU
3181 S.W. Sam Jackson Park Rd.
Portland, OR 97239-3098
ph: 503-494-7891
email Dr. Robertson through his assistant: elliojer@ohsu.edu

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nabele@nhlbi.nih.gov, elliojer@ohsu.edu

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hurt by greed, cruelty, hate.

Disaster aid for animals  +  action for all
hurt by greed, cruelty, hate.

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